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For participants alive at the time of the database cutoff date, OS was censored at the last date the participant was known to be alive. Locsl was defined as the time between the date of randomization and the date of death as a result of any cause. Survival rates were determined via Kaplan-Meier estimates.

For participants alive at the time of the database cutoff date, OS was censored at the last date the loccal was known to be alive.

OS was defined as the time between the date of randomization and the date of death as a result of any cause. Survival rates were determined via Kaplan-Meier estimates.

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Participants who were alive and did not experience a PFS event were censored at the earlier of the latest prostate-specific antigen PSA or radiological tumor assessment date. Participants who did not die, showed no clinical deterioration, and who had no recorded post-baseline PSA or radiological tumor assessment were censored at randomization date. The initial date when the pain response criterion was achieved was considered the pain response date.

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The earlier of date of tet, date of tumor resection surgery, or date when pain response criterion was no longer met was considered the completion date of the pain response. If none of these scenarios occurred, the completion of the pain response was set to the last known alive date. ImARs were collected prospectively and grouped into enterocolitis, hepatitis, dermatitis, neuropathies and endocrinopathies.

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These irAEs are AEs of unknown etiology, consistent with an immune phenomenon and considered as causally related to drug exposure. Gr 0: within normal range.

Abnormal values for WBC were based on Gr 1: 3. Abnormal values for Hemoglobin were based on Gr 1: Abnormal values for Lymphocytes were based on Gr 1: 0. Abnormal values for ANC were based on Gr 1: 1.

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Abnormal values for Platelets were based on Gr 1: Talk with your doctor and family lonelj or friends about deciding to a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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